Research Database

Clinical benefit of two-times-per-day aclidinium bromide compared with once-a-day tiotropium bromide hydrate in COPD: a multicentre, open-label, randomised study

  • Published on July 26, 2019

Objective Chronic obstructive pulmonary disease (COPD) is mainly treated pharmaceutically with bronchodilators. The purpose of this study was to evaluate the clinical benefits of two-times-per-day aclidinium bromide (Acli-BID) compared with once-a-day tiotropium bromide hydrate (Tio-QD) in patients with COPD. Design This study was a multicentre, open-label, randomised study. Setting Fourcentres ...


Exploration of associations between the FTO rs9939609 genotype, fasting and postprandial appetite-related hormones and perceived appetite in healthy men and women

  • Published on July 13, 2019

Background The fat mass and obesity-associated gene (FTO) rs9939609 A-allele has been associated with obesity risk. Although the exact mechanisms involved remain unknown, the FTO rs9939609 A-allele has been associated with an impaired postprandial suppression of appetite. Objectives To explore the influence of FTO rs9939609 genotype on fasting and postprandial ...


Physical activity change after a promotora-led intervention in low-income Mexican American women residing in South Texas

  • Published on June 19, 2019

Background The purpose of this study was to determine physical activity (PA) preferences associated with increases in moderate-to-vigorous physical activity (MVPA) and decrease in sedentary time in Mexican American (MA) women participating in a Promotora (community health worker)-led intervention on the U.S.-Mexico border. Methods Enlace (‘to link’ ...


Patterns of objectively measured sedentary behaviour in adults with intellectual disabilities

  • Published on June 13, 2019

Background The purpose of this study was to investigate the patterns of objectively measured sedentary behaviour in adults with intellectual disabilities. Methods Baseline accelerometer data were pooled from two randomized controlled trials of lifestyle behaviour change programmes for adults with intellectual disabilities. Patterns of sedentary behaviours were computed including total ...


What is the Agreement Between Two Generations of Commercial Accelerometer in a Free-Living Environment for Young to Middle-Aged Adults?

  • Published on June 9, 2019

Background Rapid change in the commercial market can threaten consistency of activity data comparisons as devices are superseded. Purpose: To determine the level of agreement between two generations of Fitbit™ device for step count and activity level in a free-living environment. Methods Thirty-seven healthy participants (17 women, 20 men; M ± SD: age 34 ± 8 ...


Moving in Sync: Hourly Physical Activity and Sedentary Behavior are Synchronized in Couples

  • Published on May 29, 2019

Background Overall time spent in moderate-to-vigorous intensity physical activity (MVPA) and sedentary behavior are both correlated in couples. Knowledge about the nature and psychosocial correlates of such dyadic covariation could inform important avenues for physical activity promotion. Purpose The present study investigates hour-by-hour covariation between partners (i.e., synchrony) in ...


Decreased serum leptin levels in male methamphetamine abusers during early abstinence: a cross-sectional study and analysis

  • Published on May 30, 2019

Abstract Objectives: To examine the differences in serum leptin levels and other relevant factors between male methamphetamine (METH) abusers during early abstinence and healthy controls. Methods: Fifty-five male METH abusers less than 2 weeks after quitting and 50 male healthy controls were enrolled. Abstinence was confirmed by daily negative urine drug screening ...


Associations of physical activity or sedentary behaviour with pain sensitivity in young adults of the Raine Study

  • Published on May 29, 2019

Background and aims There is high level evidence for physical activity (PA) improving outcomes in persistent pain disorders and one of the mechanisms proposed is the effect of exercise on central nociceptive modulation. Although laboratory studies and small field intervention studies suggest associations between physical activity and pain sensitivity, the ...



Inducing incentive sensitization of exercise reinforcement among adults who do not regularly exercise—A randomized controlled trial

  • Published on May 7, 2019

Background Increasing exercise reinforcement, or decreasing sedentary reinforcement, may reduce sedentary activity and promote habitual exercise. Repeated exposures to a reinforcer may increase its reinforcing value (i.e., incentive sensitization). It is not yet known whether incentive sensitization occurs for exercise or factors associated with incentive sensitization for exercise reinforcement. ...