Research Database

68 results for "Cardiovascular Disease"

Daily Step Count as a Simple Marker of Disease Severity in Hypertrophic Cardiomyopathy

  • Published on Jan 31, 2018

Background: Individuals with hypertrophic cardiomyopathy (HCM) may be asymptomatic or display activity-limiting symptoms. A common cause of symptoms is left ventricular outflow tract obstruction (LVOTO), which may impact the individuals' ability to undertake physical activity. This study sought to examine daily step count as a potential marker of exercise capacity, ...


Different autonomic responses to occupational and leisure time physical activities among blue-collar workers

  • Published on Nov 24, 2017

Purpose: The differential effect of occupational and leisure time physical activity on cardiovascular health is termed the physical activity health paradox. Cardiac autonomic modulation could bring insights about the underlying mechanism behind this differential effect. The aim was to compare heart rate variability (HRV) during different activities (sitting, standing and ...


Exercise Training With and Without Ranolazine in Chronic Stable Angina Patients

  • Published on Nov. 14, 2017

Introduction: An estimated seven million American adults live with coronary artery disease and chronic angina. Many continue to experience angina despite revascularization and antianginal medications. Ranolazine reduces angina frequency and increases exercise capacity. We hypothesized that exercise plus ranolazine would allow patients to train at greater intensities, leading to improvements ...


Change in Physical Activity During Active Treatment of Cardiac Patients

  • Published on April 2017

Abstract: Sedentary secular, domestic, and recreational behaviour is a major risk factor (RF) for cardiovascular disease (CVD). This study examines the quality of at-home physical activity (PA) and how it relates to physical fitness (PF) before and during 12 weeks of supervised cardiac rehabilitation (CR) in a group of medically referred ...


Association between depressive symptoms and objectively measured daily step count in individuals at high risk of cardiovascular disease in South London, UK: a cross-sectional study.

  • Published on Apr 2018

Objectives: Depressive symptoms are common but rarely considered a risk factor for unhealthy lifestyles associated with cardiovascular disease (CVD). This study investigates whether depressive symptoms are associated with reduced physical activity (PA) in individuals at high risk of developing CVD. Design: Secondary analysis of the cross-sectional baseline data from a ...


Age- and sex-related differences in heart rate variability are present despite the suitable level of accelerometer-based physical activity

  • Published on May 2015

Background: Previous studies have described the age- and sex-related differences in heart rate variability (HRV) regardless of the level of physical activity in daily life (PADL). However, such studies were based in the assessment of PADL by means of questionnaires, which present important recall limitations. The influence of age and ...


The impact of accelerometer wear location on the relationship between step counts and arterial stiffness in adults treated for hypertension and diabetes

  • Published on Aug 24, 2017

Objectives: Accelerometer placement at the wrist is convenient and increasingly adopted despite less accurate physical activity (PA) measurement than with waist placement. Capitalizing on a study that started with wrist placement and shifted to waist placement, we compared associations between PA measures derived from different accelerometer locations with a responsive ...


Objectively measured physical activity and cardiac biomarkers: A cross sectional population based study in older men

  • Published on Jan 28, 2018

Background: N-terminal pro-brain natriuretic peptide (NT-proBNP) and high sensitivity Troponin T (hsTnT) are markers of cardiac injury used in diagnosis of heart failure and myocardial infarction respectively, and associated with increased risk of cardiovascular disease. Since physical activity is protective against cardiovascular disease and heart failure, we investigated whether higher ...


Concurrent Validity of Daily Activity Data From Medtronic ICD/CRT Devices and the Actigraph GT3X Triaxial Accelerometer: A Pilot Study

  • Published on Jan 2017

Purpose: The purpose of this pilot study was to examine the concurrent validity of daily activity data from Medtronic implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy (CRT) devices and the Actigraph GT3X triaxial accelerometer in patients with heart failure (HF). Methods: Analysis of the first 16 subjects with HF ...


A Pilot Characterization of the Human Chronobiome

  • Published on Dec 07, 2017

Abstract Physiological function, disease expression and drug effects vary by time-of-day. Clock disruption in mice results in cardio-metabolic, immunological and neurological dysfunction; circadian misalignment using forced desynchrony increases cardiovascular risk factors in humans. Here we integrated data from remote sensors, physiological and multi-omics analyses to assess the feasibility of detecting ...