Research Database

48 results for "Diabetes"

Changes in regional body composition over 8 years in a randomized lifestyle trial: The look AHEAD study

  • Published on Jul 28 2016

Objective: To test the hypothesis that an 8-year intensive lifestyle intervention (ILI) suppresses aging-dependent changes in regional lean mass (LM) and fat mass (FM) among people with overweight/obesity and type 2 diabetes. Methods: Regional body composition was measured by dual-energy X-ray absorptiometry within a subset of 1,019 volunteers (45–75 years old) in ...


SCAPIS Pilot Study: Sitness, Fitness and Fatness— Is Sedentary Time Substitution by Physical Activity Equally Important for Everyone’s Markers of Glucose Regulation?

  • Published on July 2016

Background: Although moderate-to-vigorous physical activity (MVPA) is mainly recommended for glucose control, light physical activity (LIPA) may also have the potential to induce favorable changes. We investigated sedentary time (SED) substitution with equal time in LIPA and MVPA, and the association with markers of glucose regulation and insulin sensitivity after ...



Abdominal obesity as a mediator of the influence of physical activity on insulin resistance in Spanish adults

  • Published on Nov. 19, 2015

Objective: The aim of the study was to analyze the relationship between moderate-to-vigorous physical activity (MVPA) and insulin resistance (IR) in Spanish adults and to examine whether this relationship is mediated by abdominal obesity (waist circumference — WC). Methods: The cross-sectional study included 1162 healthy subjects belonging to the EVIDENT study (mean ...


A Randomised Controlled Trial to Reduce Sedentary Time in Young Adults at Risk of Type 2 Diabetes Mellitus: Project STAND (Sedentary Time ANd Diabetes)

  • Published on Dec. 1, 2015

Aims: Type 2 diabetes mellitus (T2DM), a serious and prevalent chronic disease, is traditionally associated with older age. However, due to the rising rates of obesity and sedentary lifestyles, it is increasingly being diagnosed in the younger population. Sedentary (sitting) behaviour has been shown to be associated with greater risk ...


A randomised controlled trial of a physical activity and nutrition program targeting middle-aged adults at risk of metabolic syndrome in a disadvantaged rural community

  • Published on 2015

Background: Approximately 70% of Australian adults aged over 50 are overweight or obese, with the prevalence significantly higher in regional/remote areas compared to cities. This study aims to determine if a low-cost, accessible lifestyle program targeting insufficiently active adults aged 50-69 y can be successfully implemented in a rural location, and ...


Associations of Sedentary Time with Fat Distribution in a High-Risk Population.

  • Published on Nov. 10, 2014

Purpose: The effect of sedentary behaviour on regional fat deposition, independent of physical activity remains equivocal. We examined the cross-sectional associations between objectively measured sedentary time and markers of regional fat distribution (heart, liver, visceral, subcutaneous and total body fat) in a population at a high risk of type 2 diabetes ...


Associations of Sedentary Time with Fat Distribution in a High-Risk Population.

  • Published on Nov. 10, 2014

Purpose: The effect of sedentary behaviour on regional fat deposition, independent of physical activity remains equivocal. We examined the cross-sectional associations between objectively measured sedentary time and markers of regional fat distribution (heart, liver, visceral, subcutaneous and total body fat) in a population at a high risk of type 2 diabetes ...


Effects of Reducing Sedentary Time on Glucose Metabolism in Pakistani Immigrant Men

  • Published on July 23, 2014

Purpose: To examine the association between changes in objectively measured overall physical activity (PA), with changes in fasting and postprandial plasma insulin, C-peptide and glucose concentrations, in type 2 diabetes prone Pakistani immigrant men living in Norway and to examine whether this association is explained by changes in moderate-and-vigorous PA (MVPA) ...


The Environmental Determinants of Diabetes in the Young (TEDDY) Study

  • Published on Dec. 2008

Abstract: The etiology of type 1 diabetes (T1D) remains unknown, but a growing body of evidence points to infectious agents and/or components of early childhood diet. The National Institutes of Health has established the TEDDY Study consortium of six clinical centers in the United States and Europe and a ...