Research Database

44 results for "Diabetes"


Treatment options for type 2 diabetes in adolescents and youth: a study of the comparative efficacy of metformin alone or in combination with rosiglitazone or lifestyle intervention in adolescents with type 2 diabetes

  • Published on April 8, 2007

Abstract: Despite the increased prevalence of type 2 diabetes mellitus (T2DM) in the pediatric population, there is limited information about the relative effectiveness of treatment approaches. This article describes the rationale and design of a National Institutes of Health-sponsored multi-site, randomized, parallel group clinical trial designed to test the hypothesis ...


Waist circumference and cardiorespiratory fitness are independently associated with glucose tolerance and insulin resistance in obese women

  • Published on Dec. 12, 2013

Abstract: The purpose of this study was to determine the independent associations between physical activity (PA), cardiorespiratory fitness (CRF), abdominal obesity and insulin action in obese women. We studied 141 abdominally obese women (waist circumference (WC): 106.4 Ā± 10.2 cm). PA duration (min/day) and intensity (counts/min) were obtained by accelerometry. CRF was ...


Accelerometry-measured physical activity and inflammation after gestational diabetes

  • Published on July 2013

Purpose Gestational diabetes mellitus (GDM) is associated with adverse metabolic outcomes after delivery. Physical activity practice improves the inflammatory profile; however, whether this association exists in women with prior GDM remains unknown. Our objective was to examine the cardiometabolic and inflammatory risk factors associated with accelerometer-based measures of physical activity ...


Sedentary time and markers of chronic low-grade inflammation in a high risk population

  • Published on Oct. 29, 2013

Background Sedentary behaviour has been identified as a distinct risk factor for several health outcomes. Nevertheless, little research has been conducted into the underlying mechanisms driving these observations. This study aimed to investigate the association of objectively measured sedentary time and breaks in sedentary time with markers of chronic low-grade ...


Insulin secretion and its association with physical activity, fitness and screen time in children

  • Published on Oct. 16, 2013

Objective To determine the independent associations of moderate to vigorous physical activity (MVPA), fitness, screen time, and adiposity with insulin secretion in children. Design and Methods Caucasian youth (nā€‰=ā€‰423/630), 8-10 years old, with at least one obese biological parent, were studied (QUALITY cohort). Insulin secretion was measured using HOMA2-%...


Adiposity and glucose intolerance exacerbate components of metabolic syndrome in children consuming sugar-sweetened beverages: QUALITY cohort study

  • Published on Nov. 21, 2012

Background Sugar-sweetened beverage (SSB) consumption is linked to weight gain and metabolic syndrome (MetS) components in children, but whether these associations are modified by excess weight and glucose tolerance status in children is not known. Objective The objective of this study was to examine the cross-sectional associations between SSB intake ...


How Are Physical Activity, Fitness, and Sedentary Behavior Associated With Insulin Sensitivity in Children?

  • Published on May 11, 2012

Objective To describe the associations among moderate-to-vigorous physical activity (MVPA), fitness, sedentary behavior (SB), and insulin sensitivity (IS). Research Designs & Methods Data were drawn from the baseline assessment of the QUALITY cohort, which included 630 white youth (aged 8ā€“10 years at recruitment), with at least one obese biological parent. IS was ...


Physical Activity And Sedentary Behaviour In Scottish Youth With Type 1 Diabetes

  • Presented on May 29, 2013

Physical activity can benefit the health of youth with Type 1 diabetes. Despite the benefits some studies have found patients do not always meet the physical activity recommendation of 60 minutes of moderate-to-vigorous physical activity (MVPA) per day. Physical activity and sedentary behaviour have not been measured previously in Scottish youth with ...